Clozapine N-oxide 是 Clozapine 的主要代谢产物，也是人毒蕈碱设计受体 (DREADDs) 激动剂。它可穿过血脑屏障，可激活DREADD受体hM3Dq和hM4Di。它是一种多巴胺拮抗剂，也是一种选择性毒蕈碱 M4 受体激动剂，EC50为 11 nM。

Clozapine N-oxide is a major metabolite of clozapine that can be detected in the earliest excretion time interval after clozapine administration [1]. It is produced by the action of cytochrome P450 (CYP) isoforms CYP1A2 and CYP3A4, whose activities, in turn, can be affected by drugs and disease [2]. Clozapine N-oxide is normally biologically inactive. However, it can be used in designer receptor exclusively activated by designer drugs, also known as DREADDs, technology to modulate synthetic receptors in vivo [3].

34233-69-7

C18H19ClN4O

342.83

氯氮平N-氧化;氯氮平N-氧化物

H2O:1 mg/mL
Ethanol:10 mg/mL
DMSO:6 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years