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Methotrexate metabolite
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Methotrexate metabolite图片
CAS NO:19741-14-1
包装与价格:
包装价格(元)
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
500 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
甲喋呤杂质E
DAMPA
产品介绍
Methotrexate metabolite 是甲氨蝶呤的活性代谢物,可抑制寄生虫生长。

产品描述

Methotrexate metabolite is the active metabolite of Methotrexate which is a folic acid antagonist. Methotrexate metabolite inhibits parasite growth.

体外活性

Methotrexate metabolite was the most active, with 50% inhibitory concentrations in vitro of 446 ng/ml against the antifolate-sensitive strain and 812 ng/ml against the highly resistant strain under physiological folate conditions. Methotrexate metabolite potentiates the activity of the sulfone dapsone, an inhibitor of dihydropteroate synthase, but not that of chlorcycloguanil, a known inhibitor of dihydrofolate reductase (DHFR)[2].

Cas No.

19741-14-1

分子式

C15H15N7O2

分子量

325.33

别名

甲喋呤杂质E;DAMPA

储存和溶解度

DMSO:4 mg/mL (12.30 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years