Methotrexate metabolite 是甲氨蝶呤的活性代谢物,可抑制寄生虫生长。
产品描述
Methotrexate metabolite is the active metabolite of Methotrexate which is a folic acid antagonist. Methotrexate metabolite inhibits parasite growth.
体外活性
Methotrexate metabolite was the most active, with 50% inhibitory concentrations in vitro of 446 ng/ml against the antifolate-sensitive strain and 812 ng/ml against the highly resistant strain under physiological folate conditions. Methotrexate metabolite potentiates the activity of the sulfone dapsone, an inhibitor of dihydropteroate synthase, but not that of chlorcycloguanil, a known inhibitor of dihydrofolate reductase (DHFR)[2].
Cas No.
19741-14-1
分子式
C15H15N7O2
分子量
325.33
别名
甲喋呤杂质E;DAMPA
储存和溶解度
DMSO:4 mg/mL (12.30 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years