N-Desmethyl Sildenafil是 Sildenafil 的主要代谢物。Sildenafil 是一种有效的 5 型磷酸二酯酶 (PDE5) 抑制剂。

N-Desmethyl Sildenafil (Desmethylsildenafil) is a major metabolite of Sildenafil. Sildenafil is a potent phosphodiesterase type 5 (PDE5) inhibitor.

N-Desmethyl Sildenafil increases the amplitude of electroretinogram (ERG) recorded from the dark-adapted isolated rat retina, most probably through the enhancement of the photoreceptor cell response[1]. The formation of N-Desmethyl Sildenafil is examined using CYP3A supersomes co-expressing human P450 oxidoreductase and cytochrome b5. N-Desmethyl Sildenafil is catalyzed by CYP3A4, CYP3A5, and to a lesser extent by CYP3A7[2].

139755-82-1

C21H28N6O4S

460.55

Desmethylsildenafil;UK-103,320

DMF:5 mg/mL
DMSO:PBS (pH 7.2)(1:5):0.15 mg/mL
DMSO:225mg/mL (488.5mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years