CintiRORgon 是一种首创的、口服有活力的的RORγ选择性激动剂。它通过调节 RORγ 表达的 T 淋巴免疫细胞的基因表达,提高效应子功能,降低免疫抑制,抑制肿瘤生长,提高生存率。
产品描述
Cintirorgon is a selective, oral agonist of RORγ. Cintirorgon modulates gene expression of RORγ expressing T lymphocyte immune cells.
体外活性
Upon oral administration of Cintirorgon, this agent selectively binds to the nuclear receptor transcription factor RORγ, forming a receptor complex that translocates to the nucleus, and binds to ROR response elements (ROREs), enhancing the function, proliferation and survival of type 17 T cells, including Th17 (helper T cells) and Tc17 (cytotoxic T cells). RORγ, the nuclear receptor transcription factor that is involved in Th17/Tc17 differentiation, plays a key role in immune activation.
Cas No.
2055536-64-4
分子式
C27H23F6NO6S
分子量
603.53
别名
LYC-55716
储存和溶解度
DMSO:110 mg/mL (182.26 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years