XY101 是一种有效选择性的、代谢稳定的口服 RORγ 反向激动剂，IC50 为 30 nM，Kd 为 380 nM。

XY101 is a selective, metabolically stable and orally available agonist of RORγ inverse(IC50 of 30 nM and a Kd of 380 nM).

XY101 effectively inhibits cell growth, colony formation and expression of androgen receptor (AR), AR-V7 and prostate specific antigen (PSA)[1].

XY101 exhibits significant antitumor activities during the treatment period with tumor growth inhibition and is well tolerated without obvious body weight loss[1].

2349368-16-5

C25H20F7NO4S

563.48

DMSO:225mg/mL (399.3mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years