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Thiabendazole
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Thiabendazole图片
CAS NO:148-79-8
包装与价格:
包装价格(元)
500 mg电议
1 g电议
1 mL*10 mM(in DMSO)电议

产品名称
噻菌灵
2-(4-Thiazolyl)benzimidazole
产品介绍
Thiabendazole 是具有驱虫特性的苯并咪唑衍生物。

产品描述

Thiabendazole is a benzimidazole derivative with anthelminthic property.

体外活性

Thiabendazole provokes a strong DNA-damaging activity in the human lymphoblastoid cell line that constitutively expresses human CYP1A1 cDNA, but not in the parental line, indicating that CYP1A1 is chiefly implicated in carbaryl and thiabendazole genotoxicity. [1] Thiabendazole provokes a dose- and time-dependent increase in CYP1A1 (EROD activity, protein and mRNA levels) in primary culture of rat hepatocytes. [2] Thiabendazole results in the induction of 7-ethoxyresorufin O-deethylase and 7-pentoxyresorufin O-depentylase activities, CYP1A1, CYP1A2, CYP2B1 and CYP2B1/2 mRNA levels and CYP1A2 and CYP2B1/2 apoprotein levels. Thiabendazole markedly induces GSTP1 mRNA levels, but has only a small effect on GSTT1 mRNA levels. [3] Thiabendazole is rapidly transported by passive diffusion through the human intestinal cells by comparison with the protein-bound residues which are not able to cross the intestinal barrier. Thiabendazole will be firstly metabolized to 5OH-TBZ and subsequently converted to a chemically reactive metabolic intermediate binding to proteins. [4]

体内活性

Thiabendazole results in nephrosis or hydronephrosis and this organ toxicity may lead to the high dose-dependent mortality in treated mice. Thiabendazole results in hormone imbalance and this imbalance may play an important role in the changes of the reproductive or endocrine system in treated mice. [5]

Cas No.

148-79-8

分子式

C10H7N3S

分子量

201.25

别名

噻菌灵;2-(4-Thiazolyl)benzimidazole

储存和溶解度

Ethanol:1 mg/mL (4.96 mM)
H2O:<1 mgml
DMSO:38 mg/mL (188.8 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years