NSC 65809 是 R15B 的选择性抑制剂。

NSC 65809 is a selective inhibitor of R15B.

In cells, Raphin1 caused a rapid and transient accumulation of its phosphorylated substrate, resulting in a transient attenuation of protein synthesis. In vitro, Raphin1 inhibits the recombinant R15B-PP1c holoenzyme, but not the closely related R15A-PP1c, by interfering with substrate recruitment

Raphin1 was orally bioavailable, crossed the blood-brain barrier, and demonstrated efficacy in a mouse model of Huntington's disease.

94023-67-3

C8H8Cl2N4

231.082

3-[(2,3-dichlorophenyl)methylene]carbazamidine;Raphin1

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years