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Tos-O-C4-NH-Boc
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Tos-O-C4-NH-Boc图片
CAS NO:180851-50-7
包装:500mg
市场价:450元

产品介绍
Tos-O-C4-NH-Boc是一种PROTAClinker，属于alkylether类。Boc-NH-C6-amido-C4-acid可用于合成PROTAC分子，例如BSJ-03-204。
Cas No.180851-50-7
Canonical SMILESO=C(OC(C)(C)C)NCCCCOS(=O)(C1=CC=C(C)C=C1)=O
分子式C16H25NO5S
分子量343.44
储存条件-20℃, away from moisture and light
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Tos-O-C4-NH-Boc is an alkyl ether-based PROTAC linker can be used in the synthesis of PROTACs, such as BSJ-03-204 [1].

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[1]. Wang Z, et al. Proteolysis Targeting Chimeras for the Selective Degradation of Mcl-1/Bcl-2 Derived from Nonselective Targ. J Med Chem. 2019 Aug 21.