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UK-383367
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:348622-88-8
包装与价格:
包装价格(元)
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
500 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
UK 383367
产品介绍
UK 383367 是一种有效、选择性的 BMP-1 抑制剂,IC50=44 nM,对其选择性远高于 MMP 1,2,3,9 和 14。

产品描述

UK-383367 is a procollagen C-proteinase inhibitor with IC50 of 44 nM, has excellent selectivity over MMPs.

体外活性

UK-383367 is effective at penetrating human skin. [1] UK-383367 inhibits collagen deposition with IC50 of ~2 μM. UK-383367 has modest affinity for all the PDE-4 subtypes PDE-4a, PDE-4b, PDE-4c and PDE-4d with IC50 of 1.8 μM, 1.5 μM, 2.4 μM and 0.9 μM, respectively. [2] UK-383367 is a weakly acidic compound and lipophilic. [3]

体内活性

Plasma protein binding values for UK-383367 in rat, dog and human are 95%, 93% and 94%, respectively. UK-383367 following incubation in rat plasma results in the half-life of 49?min. UK-383367 following single intravenous administration (2 mg/kg) to rat results in the plasma clearance of 157?mL min?1?kg?1, the volume of distribution of 12?L kg?1, and an elimination half-life of 0.8? hour. UK-383367 following single intravenous administration (0.5 mg/kg) to dog results in the plasma clearance of 35?mL min?1?kg?1, the volume of distribution of 4.6?L kg?1, and an elimination half-life of 1.5?hours. UK-383367 following oral administration (2 mg/kg) to dog results in Cmax of 110 ng/mL, Tmax of 0.5-1.5 hour and oral bioavilability of 13%. [3]

Cas No.

348622-88-8

分子式

C15H24N4O4

分子量

324.38

别名

UK 383367

储存和溶解度

H2O:<1 mgml
Ethanol:65 mg/mL (200.38 mM)
DMSO:65 mg/mL (200.38 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years