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Pomalidomide-PEG3-azide
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Pomalidomide-PEG3-azide图片
CAS NO:2267306-15-8
包装与价格:
包装价格(元)
50mg电议
100mg电议
500mg电议

产品介绍
Pomalidomide-PEG3-azide是一种合成的E3连接酶配体-linker偶联物(E3ligaseligand-linkerconjugate),包含基于Pomalidomide的cereblon配体和3个单元PEG的linker。
Cas No.2267306-15-8
Canonical SMILESO=C(NC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)COCCOCCOCCN=[N+]=[N-]
分子式C21H24N6O8
分子量488.45
溶解度DMSO: 200 mg/mL (409.46 mM)
储存条件-20℃, stored under nitrogen, away from moisture
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Pomalidomide-PEG3-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology[1].

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[1]. Fangqing Zhang, et al. Discovery of a new class of PROTAC BRD4 degraders based on a dihydroquinazolinone derivative and lenalidomide/pomalidomide. Bioorg Med Chem. 2020 Jan 1;28(1):115228.