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N-Boc-PEG4-bromide
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
N-Boc-PEG4-bromide图片
CAS NO:1076199-21-7
包装:250mg
市场价:3600元

产品介绍
N-Boc-PEG4-bromide是一种PROTAC连接桥，属于PEG类和Alkyl/ether类。N-Boc-PEG4-bromide可用于合成一系列PROTAC分子。N-Boc-PEG4-bromide是一种可降解(cleavable)的ADC连接桥，用于抗体药物结合物(ADCs)的合成。
Cas No.1076199-21-7
别名叔丁氧羰基-四聚乙二醇-溴代
Canonical SMILESO=C(OC(C)(C)C)NCCOCCOCCOCCBr
分子式C13H26BrNO5
分子量356.25
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

N-Boc-PEG4-bromide is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. N-Boc-PEG4-bromide is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

[1]. Jan Anderl, et al. Amatoxin-Conjugates with Improved Linkers. US20130259880A1