您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > BDP-13176
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
BDP-13176
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
BDP-13176图片
CAS NO:2290660-61-4
包装与价格:
包装价格(元)
10mM (in 1mL DMSO)电议
5mg电议
10mg电议
25mg电议

产品介绍
BDP-13176是一种有效的fascin1抑制剂,Kd值为90nM,IC50值为240nM。BDP-13176具有成为抗转移剂的潜力。
Cas No.2290660-61-4
Canonical SMILESO=C(NC1=CC=NC=C1)C(C2=C3C=NN2C4CCNCC4)=CN(CC5=CC=C(Cl)C(Cl)=C5)C3=O
分子式C24H22Cl2N6O2
分子量497.38
溶解度DMSO: 125 mg/mL (251.32 mM)
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

BDP-13176 is a potent fascin 1 inhibitor, with a Kd of 90 nM and an IC50 of 240 nM. BDP-13176 has potential as an anti-metastatic agent[1].

BDP-13176 (0-1 μM) inhibits fascin 1 bundling activity[1].

[1]. Francis S, et al. Structure-based design, synthesis and biological evaluation of a novel series of isoquinolone and pyrazolo[4,3-c]pyridine inhibitors of fascin 1 as potential anti-metastatic agents. Bioorg Med Chem Lett. 2019;29(8):1023-1029.