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Ceapin-A7
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Ceapin-A7图片
CAS NO:2323027-38-7
包装与价格:
包装价格(元)
10mM (in 1mL DMSO)电议
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
Ceapin-A7是一种内质网应激ATF6α信号的选择性阻断剂,其IC50值为0.59μM。Ceapin-A7可用于探讨ATF6α促细胞活化的机制及其在病理环境中的作用。
Cas No.2323027-38-7
别名N-(1-(2,4-双(三氟甲基)苄基)-1H-吡唑-4-基)-5-(呋喃-2-基)异恶唑-3-甲酰胺
Canonical SMILESO=C(NC1=CN(CC2=CC=C(C(F)(F)F)C=C2C(F)(F)F)N=C1)C3=NOC(C4=CC=CO4)=C3
分子式C20H12F6N4O3
分子量470.32
溶解度DMSO: 100 mg/mL (212.62 mM)
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Ceapin-A7 is a selective blocker of ATF6α signaling in response to ER stress, with an IC50 of 0.59 μM. Ceapin-A7 can be used to explore both the mechanism of activation of ATF6α and its role in pathological settings[1].

Ceapin-A7 sensitizes cells to ER stress[1].Ceapin (0.6-18.9 μM; 4.5 hours) selectively inhibits ATF6α but not ATF6β[1].

[1]. Ciara M Gallagher, et al. Ceapins are a new class of unfolded protein response inhibitors, selectively targeting the ATF6α branch. eLife. 2016; 5: e11878.