ML-210 是一种共价的选择性谷胱甘肽过氧化物酶 4 (GPX4) 抑制剂,EC50为 30 nM。它与 GPX4 硒代半胱氨酸残基结合,具有抗癌活性。
产品描述
ML-210 is a selective RAS and covalent glutathione peroxidase 4 (GPX4) inhibitor(GPX4, EC50 : 30 nM), with anti-cancer activity
体外活性
ML210,the most potent and selective of these, displayed nanomolar potency in the primary screening cell line while maintaining selectivity similar to previously identified probes.?ML210 be highly useful in identifying pathways that can potentially be used for selectively inhibiting cancer cells[1].
Cas No.
1360705-96-9
分子式
C22H20Cl2N4O4
分子量
475.33
别名
CID 49766530
储存和溶解度
DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years