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KSC-34
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
KSC-34图片
CAS NO:2226201-97-2
包装与价格:
包装价格(元)
10mM (in 1mL DMSO)电议
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
KSC-34是蛋白质二硫键异构酶A1(PDIA1)的共价修饰剂,是一种有效的PDIA1a位点选择性抑制剂,IC50为3.5μM。KSC-34对a′结构域的选择性为30倍。KSC-34在复杂蛋白质组中对PDIA表现出选择性。
Cas No.2226201-97-2
Canonical SMILESO=C(NCCNC1=NC(N(C)CCCCC2=CC=CC=C2)=NC(NCC#C)=N1)CCl
分子式C21H28ClN7O
分子量429.95
溶解度DMSO: 100 mg/mL (232.59 mM)
储存条件4℃, stored under nitrogen
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

KSC-34, a covalent modifier of protein disulfide isomerase A1 (PDIA1), is also a selective and potent a-site inhibitor of PDIA1 with an IC50 of 3.5 μM. KSC-34 displays a 30-fold selectivity for a domain over a′ domain and displays high selectivity for PDIA1 in complex proteomes with minimal engagement of other members of the PDI family[1].

KSC-34 is selective for PDIA1 over other members of the PDI family, and other cellular cysteine-containing proteins. KSC-34 contains a (4-phenylbutyl)methylamine diversity element for optimized binding to the active site of the a domain of PDIA1 with a chloroacetamide electrophile for covalent modification of C53 on PDIA1[1].

[1]. Cole KS, et al. Characterization of an A-Site Selective Protein Disulfide Isomerase A1 Inhibitor. Biochemistry. 2018;57(13):2035-2043.