| CAS NO: | 82248-59-7 |
| 规格: | ≥98% |
| 包装 | 价格(元) |
| 50mg | 电议 |
| 100mg | 电议 |
| 250mg | 电议 |
| 500mg | 电议 |
| 1g | 电议 |
| 2g | 电议 |
| 5g | 电议 |
| Molecular Weight (MW) | 291.82 |
|---|---|
| Formula | C17H21NO.HCl |
| CAS No. | 82248-59-7 (HCl salt); |
| Storage | -20℃ for 3 years in powder form |
| -80℃ for 2 years in solvent | |
| Solubility (In vitro) | DMSO: 58 mg/mL (198.8 mM) |
| Water: 2 mg/mL (6.8 mM) | |
| Ethanol: 37 mg/mL (126.8 mM) | |
| Other info | Chemical Name: (3R)-N-methyl-3-(2-methylphenoxy)-3-phenylpropan-1-amine hydrochloride InChi Key: LUCXVPAZUDVVBT-UNTBIKODSA-N InChi Code: InChI=1S/C17H21NO.ClH/c1-14-8-6-7-11-16(14)19-17(12-13-18-2)15-9-4-3-5-10-15;/h3-11,17-18H,12-13H2,1-2H3;1H/t17-;/m1./s1 SMILES Code: CC1=CC=CC=C1O[C@@H](C2=CC=CC=C2)CCNC.[H]Cl |
| Synonyms | LY 139603 HCl; LY-139603 HCl; Atomoxetine; LY139603 HCl; Tomoxetine; Tomoxetina; Tomoxetinum; (-)-Tomoxetine; Strattera; Tomoxetine hydrochloride; LY 139603; (R)-Tomoxetine hydrochloride |
| In Vitro | In vitro activity: Atomoxetine is a selective norepinephrine reuptake inhibitor with Ki of 5 nM, compared with 77 and 1451 nM for binding to serotonin and dopamine transporters. |
|---|---|
| In Vivo | In microdialysis studies, atomoxetine increases extracellular (EX) levels of NE in prefrontal cortex (PFC) 3-fold, but does not alter 5-HTEX levels. Atomoxetine also increases DAEX concentrations in PFC 3-fold, but does not alter DAEX in striatum or nucleus accumbens. Atomoxetine increases Fos by 3.7-fold in PFC, but not in the striatum or nucleus accumbens. Atomoxetine selectively inhibits the presynaptic uptake of norepinephrine in adrenergic neurons in animals, and has activity in animal models of depression. |
| Animal model | |
| Formulation & Dosage | |
| References | Neuropsychopharmacology. 2002 Nov;27(5):699-711; J Pharmacol Exp Ther. 1985 Jan ; |
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