Altenusin 是天然的非甾体真菌代谢物,是新型 FXR 选择性激动剂,EC50 值为 3.2 ± 0.2 μM。它具有明显的DPPH自由基清除活性。
产品描述
Altenusin is a natural nonsteroidal fungal metabolite, as a novel selective agonist of FXR with an EC50 value of 3.2 ± 0.2 μM.
体外活性
Treatment of primary mouse hepatocytes with altenusin inhibited oleic acid–induced steatosis in vitro [1].
体内活性
Administration of 2076A protected mice from high-fat diet (HFD)-induced obesity by reducing the body weight and fat mass by 22.9% and 50.0%, respectively. Administration of 2076A also decreased the blood glucose level from 178.3 ± 12.4 mg/dl to 116.2 ± 4.1 mg/dl and the serum insulin level from 1.4 ± 0.6 ng/dl to 0.4 ± 0.1 ng/dl[1].
Cas No.
31186-12-6
分子式
C15H14O6
分子量
290.271
储存和溶解度
DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years