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Altenusin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Altenusin图片
CAS NO:31186-12-6
包装与价格:
包装价格(元)
1 mg电议
1 mL*10 mM(in DMSO)电议

产品介绍
Altenusin 是天然的非甾体真菌代谢物,是新型 FXR 选择性激动剂,EC50 值为 3.2 ± 0.2 μM。它具有明显的DPPH自由基清除活性。

产品描述

Altenusin is a natural nonsteroidal fungal metabolite, as a novel selective agonist of FXR with an EC50 value of 3.2 ± 0.2 μM.

体外活性

Treatment of primary mouse hepatocytes with altenusin inhibited oleic acid–induced steatosis in vitro [1].

体内活性

Administration of 2076A protected mice from high-fat diet (HFD)-induced obesity by reducing the body weight and fat mass by 22.9% and 50.0%, respectively. Administration of 2076A also decreased the blood glucose level from 178.3 ± 12.4 mg/dl to 116.2 ± 4.1 mg/dl and the serum insulin level from 1.4 ± 0.6 ng/dl to 0.4 ± 0.1 ng/dl[1].

Cas No.

31186-12-6

分子式

C15H14O6

分子量

290.271

储存和溶解度

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years