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PTGR2-IN-1
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
PTGR2-IN-1图片
CAS NO:349093-44-3
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
PTGR2-IN-1是一种有效的PTGR2抑制剂,IC50为~0.7μM。PTGR2-IN-1增加了转染PTGR2的HEK293T细胞15-keto-PGE2依赖的PPARγ转录活性。
Cas No.349093-44-3
别名1-(4-(2-甲氧基苯基)哌嗪-1-基)-2-苯基乙酮
Canonical SMILESCOC1=CC=CC=C1N2CCN(C(CC3=CC=CC=C3)=O)CC2
分子式C19H22N2O2
分子量310.39
溶解度DMSO: 100 mg/mL (322.18 mM)
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

PTGR2-IN-1 is a potent PTGR2 inhibitor with an IC50 of ~0.7 μM. PTGR2-IN-1 increases 15-keto-PGE2-dependent PPARγ transcriptional activity in PTGR2-transfected HEK293T cells[1].

A screen of structural analogs of 20 identified PTGR2-IN-1, which shows substantially increased potency (>20-fold) in assays measuring either competition of 8-labeling or 15-keto-PGE2 reductase activity (IC50 = 0.6 μM) of recombinant PTGR2, as well as an inactive control compound 23. PTGR2-IN-1 (Compound 22) blocks FFF 8 labeling of endogenous PTGR2 in HEK293T cells with good potency (complete inhibition at 5 μM and ~80% inhibition at 500 nM) and excellent selectivity[1].

[1]. Parker CG, et al. Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017;168(3):527-541.e29.