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DBCO-PEG4-Maleimide
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
DBCO-PEG4-Maleimide图片
CAS NO:1480516-75-3
包装:100mg
市场价:13050元

产品介绍
DBCO-PEG4-Maleimide是一种可降解(cleavable)的ADClinker,用于抗体偶联药物(ADCs)的合成。
Cas No.1480516-75-3
Canonical SMILESO=C(NCCC(N1CC2=C(C#CC3=C1C=CC=C3)C=CC=C2)=O)CCOCCOCCOCCOCCNC(CCN4C(C=CC4=O)=O)=O
分子式C36H42N4O9
分子量674.74
溶解度DMSO: 50 mg/mL (74.10 mM)
储存条件4℃, away from moisture
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

DBCO-PEG4-Maleimide is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

[1]. Xiaotian Zhong, et al. Capped and uncapped antibody cysteines, and their use in antibody-drug conjugation. WO2017025897A2.