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SCH 32615
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
SCH 32615图片
CAS NO:83861-02-3
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
SCH32615是一种脑啡肽酶(enkephalinase,负责内源性脑啡肽降解的酶)的抑制剂。SCH32615可以增强小鼠手术和妊娠引起的镇痛作用。
Cas No.83861-02-3
Canonical SMILESOC([C@H](CC1=CC=CC=C1)N[C@H](C(NCCC(O)=O)=O)CC2=CC=CC=C2)=O
分子式C21H24N2O5
分子量384.43
溶解度DMSO: 125 mg/mL (325.16 mM)
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

SCH 32615 is an enkephalinase (the enzymes responsible for the degradation of endogenous enkephalins) inhibitor. SCH 32615 can enhance surgery- and pregnancy-induced analgesia in mice[1][2].

SCH 32615 blocks the degradation of Met5-enkephalin by isolated enkephalinase, with the Ki of 19.5 nM[3].

SCH 32615 (150 mg/kg; s.c.) enhances surgery activated endogenous analgesia in mice[1].

[1]. Jayaram A, et, al. An enkephalinase inhibitor, SCH 32615, augments analgesia induced by surgery in mice. Anesthesiology. 1995 May;82(5):1283-7. [2]. Jayaram A, et, al. SCH 32615, an enkephalinase inhibitor, enhances pregnancy-induced analgesia in mice. Anesth Analg. 1995 May;80(5):944-8. [3]. Chipkin RE, et, al. Pharmacology of SCH 34826, an orally active enkephalinase inhibitor analgesic. J Pharmacol Exp Ther. 1988 Jun;245(3):829-38.