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Bis(2-bromoethyl)ether
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Bis(2-bromoethyl)ether图片
CAS NO:5414-19-7
包装:500mg
市场价:450元

产品介绍
Bis2-bromoethylether是一种PROTAClinker,属于alkylchain类。可用于合成PROTAC分子。
Cas No.5414-19-7
别名2,2'-二溴二乙醚
Canonical SMILESBrCCOCCBr
分子式C4H8Br2O
分子量231.92
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Bis2-bromoethyl ether is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562