CAS NO: | 80366-85-4 |
包装 | 价格(元) |
250mg | 电议 |
500mg | 电议 |
Cas No. | 80366-85-4 |
别名 | [(叔丁氧羰基)氨基氧]乙酸N-琥珀酰亚胺酯 |
Canonical SMILES | O=C1CCC(N1OC(CONC(OC(C)(C)C)=O)=O)=O |
分子式 | C11H16N2O7 |
分子量 | 288.25 |
储存条件 | Store at -20℃ |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
产品描述 | Boc-NH-O-C1-NHS ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |