Fluorometholone acetate 是合成的糖皮质激素皮质类固醇及皮质类固醇酯。它有效抑制碳酸酐酶 (CA) 对hCA-I(IC50:2.18 μM)和hCA-II(IC50:17.5 μM)。它具有抗炎活性，可用于研究外部眼部炎症。

Fluorometholone Acetate is a synthetic corticosteroid, used in the treatment of steroid responsive inflammatory conditions of the eye.

Fluorometholone Acetate is a synthetic corticosteroid, used in the treatment of steroid responsive inflammatory conditions of the eye. [1]

Hourly topical administration of the drug suspension produces an average reduction of 46.8% in the polymorphonuclear leukocytes invading the corneal stroma. In the cornea, fluorometholone acetate appears to have a greater efficacy, as compared to fluorometholone alcohol, for reducing the number of leukocytes invading that tissue following an inflammatory stimulus. Animal toxicity studies of fluorometholone, including acute intraperitoneal LD50s in mice and rats, subacute oral toxicity in rats and dogs, and subacute topical ocular toxicity in rabbits have demonstrated the safety of this drug for human use. [2]

3801-06-7

C24H31FO5

418.505

NSC 47438;Flarex;Eflone;氟米龙醋酸酯;Oxylone acetate

Ethanol:<1 mgml
H2O:<1 mgml
DMSO:84 mg/mL (200.71 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years