Arimoclomol maleate 是一种热休克蛋白 (HSP) 的共诱导剂。它通过增强 HSP 表达来保护运动神经元，进而通过蛋白酶体-泛素系统直接影响蛋白质聚集和错误折叠装配体的清除

Arimoclomol maleate (BRX-220) is a heat shock protein (HSP) co-inducer.

Arimoclomol, administered for 5 d, has a protective effect against CCK-induced acute pancreatitis. Repeated CCK treatment results in the typical laboratory and morphological changes of experimentally induced pancreatitis. The pancreatic levels of HSP60 and HSP72 are significantly increased in the animals treated with Arimoclomol [1]. Arimoclomol is a co-inducer of heat shock proteins for the potential treatment of amyotrophic lateral sclerosis (ALS), the most common form of motor neuron disease [2].

289893-26-1

C18H24ClN3O7

429.85

BRX-220

DMSO:250 mg/mL (581.60 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years