2',4'-DIHYDROXYCHALCONE 作为具有 HSP90 抑制和抗真菌作用的化合物

2',4'-Dihydroxychalcone as a compound with Hsp90 inhibitory and antifungal effects

In the presence of 2',4'-DHC (8 g/mL), radial growth of Aspergillus fumigatus was inhibited 20% compared to the control, and green pigmentation was completely blocked.?The expression of the conidiation-associated genes abaA, brlA, and wetA was significantly decreased (approximately 3- to 5-fold) by treatment with 2',4'-DHC.?The expression of calcineurin signaling components, cnaA and crzA, was also significantly reduced.?The inhibitory effects of 2',4'-DHC on metabolic activity and mycelial growth were significantly enhanced by combination treatment with itraconazole and caspofungin.?Docking studies indicated that 2',4'-DHC bind to the ATPase domain of Hsp90.?2',4'-DHC act as an Hsp90-calcinurin pathway inhibitor[1].

1776-30-3

C15H12O3

240.258

2',4'-DHC;2',4'-二羟查耳酮

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years