| CAS NO: | 1464-33-1 |
| 包装 | 价格(元) |
| 5mg | 电议 |
| 10mg | 电议 |
| 25mg | 电议 |
| 50mg | 电议 |
| Cas No. | 1464-33-1 |
| 别名 | 5-羟基-4-甲氧甲基-6-甲基-3-吡啶甲醇 |
| Canonical SMILES | OC1=C(COC)C(CO)=CN=C1C |
| 分子式 | C9H13NO3 |
| 分子量 | 183.2 |
| 溶解度 | DMF: 1 mg/ml,DMSO: 5 mg/ml,Ethanol: 1 mg/ml,PBS (pH 7.2): 10 mg/ml |
| 储存条件 | -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Ginkgotoxin is a pyridoxine antimetabolite that has been found inG. biloba.1,2It inhibits pyridoxal kinase (Ki= 3 µM), the enzyme that converts pyridoxine into its active form, pyridoxal 5'-phosphate .3Ginkgotoxin (200-1,000 µM) induces seizure-like behavior in zebrafish larvae, an effect that can be reversed by PLP or GABA.4 1.Wada, K., Ishigaki, S., Ueda, K., et al.An antivitamin B6, 4'-methoxypyridoxine, from the seed of Ginkgo biloba L.Chem. Pharm. Bull.33(8)3555-3557(1985) 2.Arenz, A., Klein, M.K., Fiehe, K., et al.Occurrence of neurotoxic 4'-O-methylpyridoxine in Ginkgo biloba leaves, Ginkgo medications and Japanese Ginkgo foodPlanta Med.62(6)548-551(1996) 3.Gandhi, A.K., Desai, J.V., Ghatge, M.S., et al.Crystal structures of human pyridoxal kinase in complex with the neurotoxins, ginkgotoxin and theophylline: Insights into pyridoxal kinase inhibitionPLoS One7(7)e40954(2012) 4.Lee, G.-H., Sung, S.-Y., Chang, W.-N., et al.Zebrafish larvae exposed to ginkgotoxin exhibit seizure-like behavior that is relieved by pyridoxal-5'-phosphate, GABA and anti-epileptic drugsDis. Model. Mech.5(6)785-795(2012) |
m.cnreagent.com