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Soticlestat
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Soticlestat图片
CAS NO:1429505-03-2
包装与价格:
包装价格(元)
1 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
TAK-935
OV935
产品介绍
SoticleSTAT 是一种首创的、口服有活性的胆固醇 24-羟化酶 (cholesterol 24-Hydroxylase, CH24H) 选择性抑制剂。它可用于研究癫痫综合征。

产品描述

Soticlestat is a potent, selective and orally active cholesterol 24-hydroxylase (CYP46A1) inhibitor. It has the potential for epilepsy syndromes research.

体外活性

Soticlestat inhibits the catalytic activity of human cholesterol 24-hydroxylase (CH24H) in a concentration-dependent manner with an IC50?of 4.5 nM

体内活性

Soticlestat treatment lowers brain 24S-hydroxycholesterol in a dose-dependent manner and substantially reduceds premature deaths of APP/PS1-Tg mice at a dose lowering brain 24S-hydroxycholesterol by approximately 50%. Soticlestat can suppress potassium-evoked extracellular glutamate elevations in the hippocampus

Cas No.

1429505-03-2

分子式

C23H23N3O2

分子量

373.456

别名

TAK-935;OV935

储存和溶解度

DMSO:100 mg/mL (267.77 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years