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27-Hydroxycholesterol
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
27-Hydroxycholesterol图片
CAS NO:20380-11-4
包装与价格:
包装价格(元)
1 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议

产品名称
25(R)-27-hydroxy Cholesterol
27-羟基胆固醇
5,25R-胆甾烯-3BETA,26-二醇
产品介绍
27-Hydroxycholesterol是一种有效的、选择性的雌激素受体调节剂和肝X 受体激动剂。

产品描述

27-Hydroxycholesterol is a selective modulator of estrogen receptor and an agonist of the liver X receptor.

体外活性

27-Hydroxycholesterol, through estrogen receptor activation, triggers a deleterious effect in prostate cancer cell lines. 27-Hydroxycholesterol significantly increases cell proliferation of LNCaP and PC3 cells and this effect can be attenuated by estrogen receptor inhibitors [1]. 27-Hydroxycholesterol is an endogenous selective estrogen receptor modulator that displays significant partial agonist activity in a variety of cellular models of estrogen receptor action. It positively regulates both gene transcription and cell proliferation in cellular models of breast cancer [2]. 27-Hydroxycholesterol is an oxysterol produced from cholesterol by the monooxygenase CYP27A1, which regulates intracellular cholesterol homeostasis. 27-Hydroxycholesterol levels can be modulated by statins or direct inhibition of CYP27A1, thereby attenuating its pro-tumorigenic activities [3]. 27-hydroxylation of cholesterol is an important pathway for LXR activation in response to cholesterol overload [4].

Cas No.

20380-11-4

分子式

C27H46O2

分子量

402.65

别名

25(R)-27-hydroxy Cholesterol;27-羟基胆固醇;5,25R-胆甾烯-3BETA,26-二醇

储存和溶解度

DMF:2mg/mL (4.97 mM)
DMSO:0.1mg/mL
Ethanol:≤20mg/mL (49.66 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years