SB 204990是一种有效的、特异性ATP柠檬酸裂解酶抑制剂。

SB 204990 is an effective and specific ATP citrate lyase enzyme inhibitor.

SB204990 treatment leads to a reduction in cytosolic Ac-CoA level and is thus expected to decrease acetylated and active β-catenin levels [1].

SB 204990 is absorbed into the systemic circulation when administered orally to rats. SB 204990 causes a dose-related decrease in plasma cholesterol (by up to 46%) and triglyceride levels (by up to 80%) in rats when administered in the diet (0.05-0.25%, w/w) for 1 week. SB 204990 (25 mg/kg per day) also decreases plasma cholesterol levels (by up to 23%) and triglyceride levels (by up to 38%) in the dog, preferentially decreasing low-density lipoprotein compared with high-density lipoprotein cholesterol levels [2].

154566-12-8

C18H22Cl2O5

389.27

DMSO:100 mg/mL (256.89 mM)
H2O:10 mg/mL (25.69 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years