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Lovastatin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Lovastatin图片
CAS NO:75330-75-5
包装与价格:
包装价格(元)
20 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
Mevinolin
洛伐他汀
MK-803
产品介绍
LovaSTATin是一种 HMG-CoA 还原酶抑制剂,用于降低胆固醇。

产品描述

Lovastatin is an HMG-CoA Reductase Inhibitor, used for lowering cholesterol.

体内活性

Lovastatin is an inactive lactone that is hydrolyzed in the liver to an active f3-hydroxyacid form. This principal metabolite is the inhibitor of the enzyme HMG-CoA reductase. The Ki is 1 nM. Lovastatin and its β-hydroxyacid metabolite are highly bound to human plasma proteins. Lovastatin crosses the blood-brain and placental barriers[6]. Lovastatin produces a profound reduction of apolipoprotein-B-containing lipoproteins, especially LDL cholesterol and, to a lesser extent, plasma triglycerides, and a small increase in HDL cholesterol[7].

细胞实验

Hela cells are treated with lovastatin (0, 5, 10, 20, 40, 80, 160, 320 μg/mL) for 24 h. Cells treated with culture medium serves as a negative control. cell viability is measured using the MTT based colorimetric assay [2].

Cas No.

75330-75-5

分子式

C24H36O5

分子量

404.54

别名

Mevinolin;洛伐他汀;MK-803

储存和溶解度

DMSO:40.5 mg/mL (100 mM)
Ethanol:20.2 mg/mL (50 mM)),with gentle warming
Powder: -20°C for 3 years
In solvent: -80°C for 2 years