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Hesperetin 7-O-glucoside
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Hesperetin 7-O-glucoside图片
CAS NO:31712-49-9
包装与价格:
包装价格(元)
1 mg电议
5 mg电议
1 mL*10 mM(in DMSO)电议

产品介绍
Hesperetin 7-O-glucoside 是通过 Hesperidin 的酶促转化产生的一种人HMG-CoA还原酶抑制剂,具有降压作用,可抑制幽门螺杆菌的生长。

产品描述

Hesperetin 7-O-glucoside and prunin are direct precursors of naringin and neohesperidin, respectively, in C. aurantium. Hesperetin 7-O-glucoside shows inhibition of human HMG-CoA reductase, it also exhibits effective inhibition of the growth of Helicobacter pylori. Hesperetin 7-O-glucoside can reduce blood pressure in healthy volunteers.

体外活性

Hesperetin 7-O-glucoside (Hes-7-G) was produced by the enzymatic conversion of hesperidin by Aspergillus sojae naringinase due to the removal of the terminal rhamnose.Extracts from orange juice and peel containing the hesperidin were so treated by this enzyme that the hesperidin could also be converted to Hesperetin 7-O-glucoside . The solubility of Hesperetin 7-O-glucoside in 10% ethanol was enhanced 55- and 88-fold over those of hesperidin and hesperetin, respectively, which may make Hesperetin 7-O-glucoside more bioavailable. Hesperetin 7-O-glucoside was 1.7- and 2.4-fold better than hesperidin and hesperetin, respectively, in the inhibition of human intestinal maltase. Hesperetin 7-O-glucoside was more potent by 2- and 4-fold than hesperidin in the inhibition of human HMG-CoA reductase. Additionally, Hesperetin 7-O-glucoside exhibited more effective inhibition of the growth of Helicobacter pylori than hesperetin, while its effectiveness was similar to that of hesperidin.

Cas No.

31712-49-9

分子式

C22H24O11

分子量

464.42

储存和溶解度

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years