Eflornithine hydrochloride Monohydrate 是一种特异性的、不可逆的酶鸟氨酸脱羧酶抑制剂。它可用于研究非洲锥虫病和女性面部毛发过度生长。

Eflornithine hydrochloride is a specific, irreversible inhibitor of ornithine decarboxylase.

When cultured cells are treated with α-difluoromethyl-Orn, an inhibitor of polyamine biosynthesis, production of hydrogen peroxide is suppressed and programmed cell death did not occur[1].

Eflornithine is the only new molecule registered for the treatment of human African trypanosomiasis over the last 50 years. It is the drug used mainly as a back-up for melarsoprol refractory Trypanosoma brucei gambiense cases[2]. Eflornithine 15% cream is superior to a placebo in reducing hair growth in subjects with excessive, unwanted facial hair. After 24 weeks' treatment, 58% of eflornithine and 34% of placebo subjects have at least some improvement in facial hirsutism[3]. The hair growth inhibitory activity of eflornithine is significantly enhanced when the eflornithine cream is applied onto a mouse skin area pretreated with microneedles[4]. Treatment of coarctation hypertensive rats with eflornithine results in a normalization of the contractile intensity to KCI and norepinephrine and relaxations to acetylcholine by 14 days of hypertension[5].

BY2 cells are treated with or without cryptogein in the presence or absence of DFMO(Difluoromethylornithine) and monitered the effect of chemicals on cell growth. (Only for Reference)

96020-91-6

C6H15ClF2N2O3

236.64

Eflornithine hydrochloride Monohydrate;依氟鸟氨酸盐酸盐一水合物;Difluoromethylornithine hydrochloride hydrate;RMI-71782 hydrochloride hydrate;Eflornithine hydrochloride;α-difluoromethylornithine hydrochloride hydrate;DFMO hydrochloride hydrate;MDL-71782 hydrochloride hydrate

DMSO:2.5 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years