Lactisole 是葡萄糖感应受体的抑制剂。

Lactisole is an inhibitor of the glucose-sensing receptor

In MIN6 cells, in a dose-dependent manner, lactisole inhibited insulin secretion induced by sweeteners, acesulfame-K, sucralose and glycyrrhizin. The IC50 was ～4 mmol/l. Lactisole attenuated the elevation of cytoplasmic Ca2+ concentration ([Ca2+]c) evoked by sucralose and acesulfame-K but did not affect the elevation of intracellular cAMP concentration ([cAMP]c) induced by these sweeteners. Lactisole also inhibited the action of glucose in MIN6 cells. Thus, lactisole significantly reduced elevations of intracellular [NADH] and intracellular [ATP] induced by glucose, and also inhibited glucose-induced insulin secretion[1].

150436-68-3

C10H12NaO4

219.19

2-(4-甲氧基苯氧基)丙酸;na-PMP

Ethanol:1 mg/mL
DMF:20 mg/mL
DMSO:10 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years