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Phloretin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Phloretin图片
CAS NO:60-82-2
包装与价格:
包装价格(元)
20 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
RJC 02792
NSC 407292
根皮素
Dihydronaringenin
产品介绍
Phloretin 是从苹果树叶中提取的一种查耳酮,具有抗炎、抗氧化和抗癌活性。它是真核尿素转运蛋白抑制剂,可阻断 VacA 介导的尿素和离子转运,有潜力用于类风湿性关节炎和过敏性气道炎症的相关研究。

产品描述

Phloretin is a well-known inhibitor of eukaryotic urea transporters, blocks VacA-mediated urea and ion transport. Phloretin is a dihydrochalcone, a type of natural phenols. It can be found in apple tree leaves and the Manchurian apricot. It promotes potent antioxidative activities in peroxynitrite scavenging and the inhibition of lipid peroxidation. It has been found to inhibit the growth of several cancer cells and induce apoptosis of B16 melanoma and HL60 human leukemia cells.

体外活性

Phloretin is a dihydrochalcone found in the bark of pear (Pyrus communis), apple, cherry and other fruit trees. Phloretin inhibits the active transport of glucose into cells by SGLT1 and SGLT2, though the inhibition is weaker than by its glycoside phlorizin. [1] Orally consumed phlorizin is nearly entirely converted into phloretin by hydrolytic enzymes in the small intestine. An important effect of this is the inhibition of glucose absorption by the small intestine and the inhibition of renal glucose reabsorption. [2] [3] Phloretin also inhibits a variety of urea transporters. It induces urea loss and diuresis when coupled with high protein diets. [4]

Cas No.

60-82-2

分子式

C15H14O5

分子量

274.272

别名

RJC 02792;NSC 407292;根皮素;Dihydronaringenin

储存和溶解度

Ethanol:48 mg/mL(175 mM)
H2O:<1 mgml
DMSO:54 mg/mL (196.89 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years