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Marein
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Marein图片
CAS NO:535-96-6
包装与价格:
包装价格(元)
5 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
马里苷
马里甙
产品介绍
Marein 能通过CaMKK/AMPK/GLUT1促进葡萄糖摄取,IRS/Akt/GSK-3β增加糖原合成,并通过Akt/FOXO1减少糖异生,从而改善 HepG2 细胞中高葡萄糖诱导的胰岛素抵抗。它对甲基乙二醛诱导的 PC12 细胞损伤具有神经保护作用,还有抗氧化、降压、降血脂和抗糖尿病作用。

产品描述

Marein shows neuroprotective effect on PC12 cell damage induced by methylglyoxal, which is due to a reduction of damage to mitochondria function and activation of the AMPK signal pathway, it may be a potent compound for preventing/counteracting diabetic encephalopathy.

体外活性

To clarify whether Marein, a major compound from the hypoglycemic plant Coreopsis tinctoria, prevents PC12 cell damage induced by MG, we cultured PC12 cells in the presence of MG and Marein. Marein attenuated MG-induced changes in the mitochondrial membrane potential (ΔΨm), mitochondrial permeability transition pores (mPTPs), intracellular Ca2+ levels, the production of reactive oxygen species (ROS), glutathione (GSH)/glutathione disulfide (GSSG) and adenosine triphosphate (ATP), and the increase in the percentage of apoptotic cells. Marein also increased glyoxalase I (Glo1) activity, phospho-AMPKα± (Thr172) and Bcl-2 expression and diminished the activation of Bax, caspase-3 and inhibitor of caspase-activated deoxyribonuclease (ICAD). Importantly, pretreatment of cells with Marein diminished the compound C-induced inactivation of p-AMPK. Molecular docking simulation showed that Marein interacted with the γ subunit of AMPK[1]

Cas No.

535-96-6

分子式

C21H22O11

分子量

450.39

别名

马里苷;马里甙

储存和溶解度

DMSO:60 mg/ml (133.21 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years