NAcM-OPT HCl(2089293-61-6 free base) 是一种可口服的 cullin neddylation 1 (DCN1) 抑制剂,靶向 N-Acetyl-UBE2M(E2 结合酶,UBC12)与 DCN1 的相互作用,IC50 为 79 nM。
产品描述
NAcM-OPT HCL is an orally bioavailable cullin neddylation 1 (DCN1) inhibitor that targets N-Acetyl-UBE2M (E2 conjugating enzyme, UBC12) interaction with DCN1 with IC50 of 79 nM.
体内活性
NAcM-OPT is orally bioavailable, well tolerated in mice, and currently used to study the effects of acute pharmacologic inhibition of the DCN1-UBE2M interaction on the NEDD8/CUL pathway
Cas No.
2416146-10-4
分子式
C23H30Cl3N3O
分子量
470.86
储存和溶解度
DMSO:60 mg/ml (127.43 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years