Peretinoin 是口服非环状类视黄醇，靶向类视黄醇核受体，结构类维生素 A 。

Peretinoin is an oral acyclic retinoid with a vitamin A-like structure that targets retinoid nuclear receptors such as RXR and RAR.

Peretinoin (10-40 μM; 12-72 hours) exhibits suppressed SPHK1 expression after 24 h treatment, even at 10 μM and more prominent after 72 h peretinoin treatment [1]. Peretinoin (5 μM; 24 hours) up-regulates the expression of LC3B-II and increases autophagy flux in mouse primary hepatocytes [2]. Peretinoin inhibits HCV RNA amplification and virus release by altering lipid metabolism with an EC50 of 9 μM [3].

Cell Line: Mouse primary hepatocytes (MPH) and the human HCC HepG2 cell line. Concentration: 5 μM. Incubation Time: 24 hours [2]

81485-25-8

C20H30O2

302.45

NIK333

DMSO:50 mg/mL (165.32 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years