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BMS453
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
BMS453图片
CAS NO:166977-43-1
包装与价格:
包装价格(元)
1 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议

产品名称
BMS-189453
BMS 453
产品介绍
BMS 453 是一种合成类维生素 A,是一种RARβ激动剂,也是一种RARα/RARγ拮抗剂。它主要通过诱导活性 TGFβ 来抑制乳腺细胞生长。

产品描述

BMS453, a synthetic retinoid, is a potent and selective agonist of RARβ and a potent testicular toxin. BMS453 inhibits breast cell growth predominantly through the induction of active TGFβ.

体外活性

BMS453 (1 μM; 11 hours; 184 and HMEC cells) treatment inhibits the proliferation of normal breast cell growth without significantly inducing apoptosis[2]. The RARβ-selective agonist (BMS453), but not RARα- or RARγ-selective agonists (BMS753 and BMS961, respectively), significantly reduced the T47D breast cancer cell migration to levels comparable to inhibition by RA, indicating that RARβ is involved in RA-inhibited cell migration[3].

Cas No.

166977-43-1

分子式

C27H24O2

分子量

380.487

别名

BMS-189453;BMS 453

储存和溶解度

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years