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Ospemifene-d4
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Ospemifene-d4图片
包装与价格:
包装价格(元)
1mg电议
5mg电议

产品介绍
别名FC-1271a D4
Canonical SMILESClCC/C(C1=CC=CC=C1)=C(C2=CC=CC=C2)/C3=CC=C(C=C3)OC([2H])([2H])C([2H])([2H])O
分子式C24H19ClD4O2
分子量382.9
溶解度Acetonitrile: soluble
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Ospemifene-d4is intended for use as an internal standard for the quantification of ospemifene by GC- or LC-MS. Ospemifene is a non-hormonal selective estrogen receptor modulator (SERM).1It binds to estrogen receptor α (ERα) and ERβ (Kis = 380 and 410 nM, respectively). It increases vaginal weight and vaginal epithelial height (ED50s = 0.48 and 0.39 mg/kg per day, respectively) in an ovariectomized rat model of menopause. Ospemifene also increases progesterone receptor protein expression in vaginal epithelium and stroma and inhibits estrogen response element-mediated transactivation induced by 17β-estradiol in a reporter assay using MCF-7 cells. Formulations containing ospemifene have been used in the treatment of vulvar and vaginal atrophy-induced dyspareunia.

1.Unkila, M., Kari, S., Yatkin, E., et al.Vaginal effects of ospemifene in the ovariectomized rat preclinical model of menopauseJ. Steroid Biochem. Mol. Biol.138107-115(2013)