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Levamisole hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Levamisole hydrochloride图片
CAS NO:16595-80-5
包装与价格:
包装价格(元)
500 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
(-)-Tetramisole hydrochloride
盐酸左旋咪唑
产品介绍
Levamisole hydrochloride 是驱虫剂和免疫调节剂。它对HSV病毒有明显抗病毒作用。

产品描述

Levamisole hydrochloride is an antihelminthic drug that has been tried experimentally in rheumatic disorders where it apparently restores the immune response by increasing macrophage chemotaxis and T-lymphocyte function. Paradoxically, this immune enhancement appears to be beneficial in rheumatoid arthritis where dermatitis, leukopenia, and thrombocytopenia, and nausea and vomiting have been reported as side effects.

体外活性

L-tetramisole (250 and 500 mg/mL) suppresses IFN synthesis in the cells from BALB/c and NZB mice. L-tetramisole (125 mg/mL) inhibits the IFN production only partially and this effect is observed when the IFN production is high. L-tetramisole affects the production of the physiological IFN, but not the production of IFN induced by Newcastle disease virus (NDV) in the peritoneal cells of mice or in L929 cells. [1]

体内活性

Tetramisole leads to the mean faecal egg count rose from 3 weeks after treatment and remain continuously higher than those Closantel or Albendazole treated group up to 12 weeks after treatment. [2] Tetramisole reduces neuronal response amplitude in a dose-dependent manner in mouse cortex. Tetramisole also decreases axonal conduction velocity in mouse cortex. [3] Tetramisole significantly increases the stereotyped behavior (grooming, sniffing, biting and licking and head bobbing) of the mice when compared to the control group. Tetramisole significantly increases stereotyped behavior of the mice on days 3, 5 and 8 in comparison with respective control values. Tetramisole treatments (0.5 and 1 mg/kg) also significantly decreases the time needed to complete the negative geotaxis task and reduces landing foot splay. [4]

Cas No.

16595-80-5

分子式

C11H13ClN2S

分子量

240.75

别名

(-)-Tetramisole hydrochloride;盐酸左旋咪唑

储存和溶解度

DMSO:15.5 mg/mL (64.38 mM),Need ultrasonic and warming
Powder: -20°C for 3 years
In solvent: -80°C for 2 years