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Ticagrelor-d7
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Ticagrelor-d7图片
CAS NO:1265911-55-4
包装:1mg
市场价:6426元

产品介绍
An internal standard for the quantification of ticagrelor
Cas No.1265911-55-4
别名替卡格雷 d7
Canonical SMILESFC(C(F)=C1)=CC=C1[C@@H]2C[C@H]2NC3=C4C(N([C@@H]5C[C@H](OCCO)[C@@H](O)[C@H]5O)N=N4)=NC(SC([2H])([2H])C([2H])([2H])C([2H])([2H])[2H])=N3
分子式C23H21D7F2N6O4S
分子量529.6
溶解度DMF: 25 mg/ml,DMSO: 20 mg/ml,Ethanol: 15 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Ticagrelor-d7is intended for use as an internal standard for the quantification of ticagrelor by GC- or LC-MS. Ticagrelor is a reversible antagonist of the platelet purinergic P2Y12receptor (Ki= 14 nM; IC50= 1.8 μM), which is the main receptor responsible for ADP-induced platelet aggregation.1,2It functions by directly changing the conformation of the P2Y12receptor to inhibit ADP binding.3Formulations containing ticagrelor have been used to reduce the rate of thrombotic cardiovascular events in patients with acute coronary syndrome.

1.Zech, G., Hessler, G., Evers, A., et al.Identification of high-affinity P2Y12 antagonists based on a phenylpyrazole glutamic acid piperazine backboneJ. Med. Chem.55(20)8615-8629(2012) 2.Michelson, A.D.Advances in antiplatelet therapyHematology Am. Soc. Hematol. Educ. Program2011(1)62-69(2011) 3.Wallentin, L.P2Y12 inhibitors: Differences in properties and mechanisms of action and potential consequences for clinical useEur. Heart J.30(16)1964-1977(2009)