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N2-Isobutyryl-5′-O-(4,4′-dimethoxytrityl)-2′-deoxyguanosine
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
N2-Isobutyryl-5′-O-(4,4′-dimethoxytrityl)-2′-deoxyguanosine图片
CAS NO:68892-41-1
包装:500mg
市场价:499元

产品介绍
N2-Isobutyryl-5′-O-(4,4′-dimethoxytrityl)-2′-deoxyguanosine (N2-Isobutyryl-5′-O-(4,4′-dimethoxytrityl)-2′-deoxyguanosine) is a deoxynucleoside which可用于制备寡核苷酸。
Cas No.68892-41-1
别名5'-O-(4,4'-二甲氧基三苯基)-N2-异丁酰基-2'-脱氧鸟甙,N2-Isobutyryl-5′-O-(4,4′-dimethoxytrityl)-2′-deoxyguanosine
Canonical SMILESO=C1N=C(NC(C(C)C)=O)NC2=C1N=CN2[C@@]3([H])C[C@H](O)[C@@H](COC(C4=CC=C(OC)C=C4)(C5=CC=CC=C5)C6=CC=C(OC)C=C6)O3
分子式C35H37N5O7
分子量639.7
溶解度DMF: 15mg/mL,DMSO: 15mg/mL,Ethanol: 30mg/mL,Ethanol:PBS (pH 7.2) (1:3): 0.25mg/mL
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

N2-Isobutyryl-5′-O-(4,4′-dimethoxytrityl)-2′-deoxyguanosine is a building block that has been used in the synthesis of oligodeoxyribonucleotides.1,2,3

1.Wilk, A., Grajkowski, A., Phillips, L.R., et al.The 4-[N-Methyl-N-(2,2,2-trifluoroacetyl)amino]butyl group as an alternative to the 2-cyanoethyl group for phosphate protection in the synthesis of oligodeoxyribonucleotidesJ. Org. Chem.64(20)7515-7522(1999) 2.Grajkowski, A., Pedras-Vasconcelos, J., Wang, V., et al.Thermolytic CpG-containing DNA oligonucleotides as potential immunotherapeutic prodrugsNucleic Acids Res.33(11)3550-3560(2005) 3.Cie?lak, J., and Beaucage, S.L.Thermolytic properties of 3-(2-pyridyl)-1-propyl and 2-[N-methyl-N-(2-pyridyl)]aminoethyl phosphate/thiophosphate protecting groups in solid-phase synthesis of oligodeoxyribonucleotidesJ. Org. Chem.68(26)10123-10129(2003)