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Minoxidil-d10
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Minoxidil-d10图片
CAS NO:1020718-66-4
包装与价格：
包装价格(元)
500 μg电议
1mg电议
5mg电议
10mg电议

产品介绍
An internal standard for the quantification of minoxidil
Cas No.1020718-66-4
别名米诺地尔-d10
Canonical SMILESNC1=[N+]([O-])C(N)=NC(N2C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C2([2H])[2H])=C1
分子式C9H5D10N5O
分子量219.3
溶解度DMF: 2 mg/ml,DMSO: 2 mg/ml,Ethanol: 5 mg/ml,PBS (pH 7.2): 2 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Minoxidil-d10contains 10 deuterium atoms on the piperidine ring. It is intended for use as an internal standard for the quantification of minoxidil by GC- or LC-mass spectrometry. Minoxidil is a pyrimidine derivative that was originally developed as an anti-hypertensive agent and unexpectedly found to stimulate hair growth. Minoxidil directly affects arteriolar smooth muscle to decrease vascular resistance in part by opening ATP-sensitive potassium channels.1,2It can activate cyclooxygenase 1 (AC50= 80 μM), which is expressed in the dermal papilla of hair follicles, increasing prostaglandin E2production in BALB/c 3T3 fibroblasts and human dermal papilla fibroblasts.3

1.Limas, C.J., and Cohn, J.N.Stimulation of vascular smooth muscle sodium, potassium--adenosinetriphosphatase by vasodilatorsCirculation Research35(4)601-607(1974) 2.Imenshahidi, M., Hadizadeh, F., Firoozeh-Moghadam, A., et al.Synthesis and vasorelaxant effect of 9-aryl-1,8-acridinediones as potassium channel openers in isolated rat aortaIran.J.Pharm.Res.11(1)229-233(2012) 3.Michelet, J.F., Commo, S., Billoni, N., et al.Activation of cytoprotective prostaglandin synthase-1 by minoxidil as a possible explanation for its hair growth-stimulating effectJournal of Investigative Dermatology108205-209(1997)