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Esmolol-d7(hydrochloride)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Esmolol-d7(hydrochloride)图片
CAS NO:1346598-13-7
包装与价格:
包装价格(元)
500 μg电议
1mg电议
5mg电议
10mg电议

产品介绍
An internal standard for the quantification of esmolol
Cas No.1346598-13-7
别名盐酸艾司洛尔 d7 (盐酸盐)
Canonical SMILESOC(COC1=CC=C(CCC(OC)=O)C=C1)CNC(C([2H])([2H])[2H])([2H])C([2H])([2H])[2H].Cl
分子式C16H18D7NO4.HCl
分子量338.9
溶解度Methanol: soluble
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Esmolol-d7is intended for use as an internal standard for the quantification of esmolol by GC- or LC-MS. Esmolol is a β1-adrenergic receptor (β1-AR) antagonist.1It binds to β1-ARs (Kd= 100 nM in isolated cardiac myocytes) and is 34-fold selective for β1- over β2-ARs.1,2Esmolol also inhibits L-type Ca2+currents (ICa.L) and the fast Na+current (INa) in rat cardiac myocytes (IC50s = 50 and 169 μM, respectively), which results in complete ventricular arrest at concentrations greater than or equal to 1 mM.1Formulations containing esmolol have been used in the treatment of cardiac arrhythmias, postoperative hypertension, and acute ischemic heart disease, as well as to minimize myocardial contraction during cardiac surgery and attenuate the adrenergic response associated with tracheal intubation.

1.Fallouh, H.B., Bardswell, S.C., McLatchie, L.M., et al.Esmolol cardioplegia: The cellular mechanism of diastolic arrestCardiovasc. Res.87(3)552-560(2010) 2.Jahn, P., Eckrich, B., Schneidrowski, B., et al.β1-adrenoceptor subtype selective antagonism of esmolol and its major metabolite in vitro and in man. Investigations using tricresylphosphate as red blood cell carboxylesterase inhibitorArznei.-Forschung45(5)536-541(1995)