S-(1-Hydroxy-2-methylpropan-2-yl)methanesulfonothioate

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CAS NO:

2127875-65-2

包装与价格：

产品介绍

S-(1-Hydroxy-2-methylpropan-2-yl)methanesulfonothioate是一种谷胱甘肽可降解(cleavable)的ADClinker，用于抗体偶联药物(ADCs)，属于Alkyl-Chain类，是ADCs用于mAb附着的连接体部分。

Cas No.	2127875-65-2
Canonical SMILES	CC(SS(C)(=O)=O)(C)CO
分子式	C₅H₁₂O₃S₂
分子量	184.28
储存条件	4°C, protect from light, stored under nitrogen
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
产品描述	S-(1-Hydroxy-2-methylpropan-2-yl) methanesulfonothioate is a glutathione cleavable ADC linker used for the antibody-drug conjugates (ADCs) and refers to the Alkyl-Chain composition. S-(1-Hydroxy-2-methylpropan-2-yl) methanesulfonothioate is the linker portions of the molecules employed for mAb attachment purposes[1]. [1]. Pillow TH, et al. Antibody Conjugation of a Chimeric BET Degrader Enables in vivo Activity. ChemMedChem. 2019 Oct 31.