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Propargyl-PEG2-amine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Propargyl-PEG2-amine图片
CAS NO:944561-44-8
包装:100mg
市场价:900元

产品介绍
Propargyl-PEG2-amine是一种不可降解(non-cleavable)的ADClinker,用于抗体偶联药物(ADCs)的合成。Propargyl-PEG2-amine是一种PROTAClinker,属于PEG类。Propargyl-PEG2-NH2可用于合成一系列PROTAC分子。
Cas No.944561-44-8
别名2-(2-(丙-2-炔-1-基氧基)乙氧基)乙胺
Canonical SMILESNCCOCCOCC#C
分子式C7H13NO2
分子量143.18
储存条件4°C, protect from light, stored under nitrogen
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Propargyl-PEG2-amine is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG2-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1][2].

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

[1]. Changchun Wang, et al. A kind of antibody coupling matter and its construction method containing boron ester units polymer. CN108721642A. [2]. Guangrong Zheng, et al. Bcl-2 proteins degraders for cancer treatment. WO2019144117A1.