| CAS NO: | 2271036-44-1 |
| 包装: | 100mg |
| 市场价: | 8820元 |
| Cas No. | 2271036-44-1 |
| 别名 | Cereblon Ligand-Linker Conjugates 13; E3 ligase Ligand-Linker Conjugates 50 |
| Canonical SMILES | O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3NCCOCCN=[N+]=[N-])=O |
| 分子式 | C17H18N6O5 |
| 分子量 | 386.36 |
| 储存条件 | -20℃, stored under nitrogen |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Pomalidomide-PEG1-C2-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 1-unit PEG linker used in PROTAC technology. Pomalidomide-PEG1-C2-N3 can be used to design a selective CDK6 PROTAC degrader CP-10. CP-10 induces the degradation of CDK6 with an DC50 of 2.1 nM[1]. [1]. Su S, et al. Potent and Preferential Degradation of CDK6 via Proteolysis Targeting Chimera Degraders. J Med Chem. 2019 Aug 2. |
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