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Bis-PEG6-acid
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Bis-PEG6-acid图片
CAS NO:119189-70-7
包装与价格:
包装价格(元)
250mg电议
500mg电议

产品介绍
Bis-PEG6-acid 是一种 PROTAC linker,属于 PEG 类。Bis-PEG5-propionic acid 可用于合成一系列 PROTAC 分子。
Cas No.119189-70-7
别名羧酸-五聚乙二醇-羧酸
Canonical SMILESOC(CCOCCOCCOCCOCCOCCOCCC(O)=O)=O
分子式C16H30O10
分子量382.4
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Bis-PEG6-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

[1]. Zorba A, et al. Delineating the role of cooperativity in the design of potent PROTACs for BTK. Proc Natl Acad Sci U S A. 2018 Jul 31;115(31):E7285-E7292.