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Bis-PEG2-acid
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Bis-PEG2-acid图片
CAS NO:19364-66-0
包装与价格:
包装价格(元)
250mg电议
500mg电议

产品介绍
Bis-PEG2-acid 是一种 PROTAC linker,属于 PEG 类。Bis-PEG1-propionic acid 可用于合成一系列 PROTAC 分子。
Cas No.19364-66-0
Canonical SMILESO=C(O)CCOCCOCCC(O)=O
分子式C8H14O6
分子量206.19
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Bis-PEG2-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

[1]. Zhao Q, et al. Discovery of SIAIS178 as an Effective BCR-ABL Degrader by Recruiting Von Hippel-Lindau (VHL) E3 Ubiquitin Ligase. J Med Chem. 2019 Oct 24;62(20):9281-9298.