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Bis-PEG1-acid
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Bis-PEG1-acid图片
CAS NO:5961-83-1
包装与价格:
包装价格(元)
100mg电议
250mg电议

产品介绍
Bis-PEG1-acid 是一种 PROTAC linker,属于 PEG 类。Bis-PEG1-acid 可用于合成 PROTAC 分子。
Cas No.5961-83-1
别名二(2-羧基乙基)醚
Canonical SMILESO=C(O)CCOCCC(O)=O
分子式C6H10O5
分子量162.14
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Bis-PEG1-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.